| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-05-02 |
| タイトル |
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タイトル |
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
obsessive-compulsive disorder |
| キーワード |
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主題Scheme |
Other |
|
主題 |
computational model |
| キーワード |
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主題Scheme |
Other |
|
主題 |
reinforcement learning |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
decision making |
| キーワード |
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主題Scheme |
Other |
|
主題 |
credit assignment |
| キーワード |
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主題Scheme |
Other |
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主題 |
memory trace |
| キーワード |
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主題Scheme |
Other |
|
主題 |
eligibility trace |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
prediction error |
| キーワード |
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主題Scheme |
Other |
|
主題 |
serotonin reuptake inhibitor |
| キーワード |
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主題Scheme |
Other |
|
主題 |
behavioral therapy |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Sakai, Yuki
Sakai, Yutaka
Abe, Yoshinari
Narumoto, Jin
田中, 沙織
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We may view most of our daily activities as rational action selections; however, we sometimes reinforce maladaptive behaviors despite having explicit environmental knowledge. In this study, we model obsessive-compulsive disorder (OCD) symptoms as implicitly learned maladaptive behaviors. Simulations in the reinforcement learning framework show that agents implicitly learn to respond to intrusive thoughts when the memory trace signal for past actions decays differently for positive and negative prediction errors. Moreover, this model extends our understanding of therapeutic effects of behavioral therapy in OCD. Using empirical data, we confirm that patients with OCD show extremely imbalanced traces, which are normalized by serotonin enhancers. We find that healthy participants also vary in their obsessive-compulsive tendencies, consistent with the degree of imbalanced traces. These behavioral characteristics can be generalized to variations in the healthy population beyond the spectrum of clinical phenotypes. |
| 書誌情報 |
en : Cell Reports
巻 40,
号 9,
発行日 2022-08-30
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| 出版者 |
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出版者 |
Cell Press |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2211-1247 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.celrep.2022.111275 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.sciencedirect.com/science/article/pii/S2211124722010956?via%3Dihub |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A9 2022 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
NA |
