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Precision Mapping of Thalamic Deep Brain Stimulation Lead Positions Associated With the Microlesion Effect in Tourette Syndrome
http://hdl.handle.net/10061/0002000212
http://hdl.handle.net/10061/0002000212288efa40-0984-4ed2-be94-dfcf00b145bd
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2024-04-30 | |||||||||||||||||||
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| タイトル | Precision Mapping of Thalamic Deep Brain Stimulation Lead Positions Associated With the Microlesion Effect in Tourette Syndrome | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Tourette syndrome | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Deep brain stimulation | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Thalamus | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Adverse events | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Microlesion effect | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| 著者 |
Morishita, Takashi
× Morishita, Takashi
× Sakai, Yuki
× Iida, Hitoshi
× Yoshimura, Saki
× Fujioka, Shinsuke
× Oda, Kazunori
× 田中, 沙織× Abe, Hiroshi
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | BACKGROUND: The microlesion effect refers to the improvement of clinical symptoms after deep brain stimulation (DBS) lead placement and is suggested to indicate optimal lead placement. Very few studies have reported its implications in neuropsychiatric disorders. OBJECTIVE: To evaluate the magnitude of the microlesion effect in Tourette syndrome and the relationship between the microlesion effect and the anatomic location of implanted DBS leads. METHODS: Six male patients were included. Their median age at surgery and follow-up period were 25 years (range, 18-47) and 12 months (range, 6-24), respectively. All patients were videotaped pre- and postoperatively, and tic frequencies were counted. We also analyzed the precision of lead placement and evaluated the normative connectome associated with the microlesion area. RESULTS: The microlesion effect was observed as an improvement in tic symptoms in all patients, and the long-term clinical outcomes were favorable. The median motor tic frequency was 20.2 tics/min (range, 9.7-60) at baseline and decreased to 3.2 tics/min (1.2-11.3) in patients on postoperative day 1 (P = .043) and to 5.7 tics/min (range, 1.9-16.6) in patients on postoperative day 7 (P = .028). Phonic tic tended to improve immediately after surgery although the changes were not significant. Image analyses revealed that the precise position of the electrode was directed toward the anteromedial centromedian nucleus. Normative connectome analysis demonstrated connections between improvement-related areas and wide areas of the prefrontal cortex. CONCLUSION: This study shows that the microlesion effect may seem as an immediate improvement after optimal DBS lead placement in patients with Tourette syndrome. |
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| 書誌情報 |
en : Neurosurgery 巻 93, 号 4, p. 875-883, 発行日 2023-04-14 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Wolters Kluwer | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 1524-4040 | |||||||||||||||||||
| 出版者版DOI | ||||||||||||||||||||
| 関連タイプ | isReplacedBy | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1227/neu.0000000000002484 | |||||||||||||||||||
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| 関連タイプ | isReplacedBy | |||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||
| 関連識別子 | https://journals.lww.com/neurosurgery/fulltext/2023/10000/precision_mapping_of_thalamic_deep_brain.19.aspx | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||
| 権利情報 | $00A9 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Congress of Neurological Surgeons. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | |||||||||||||||||||
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| 出版タイプ | NA | |||||||||||||||||||
