| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-24 |
| タイトル |
|
|
タイトル |
Distinctive alterations in the mesocorticolimbic circuits in various psychiatric disorders |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
autism spectrum disorder |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
dynamic causal modeling |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
major depressive disorder |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
mesocorticolimbic circuits |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
schizophrenia |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Nakamura, Yuko
Ishida, Takuya
田中, 沙織
Mitsuyama, Yuki
Yokoyama, Satoshi
Shinzato, Hotaka
Itai, Eri
Okada, Go
Kobayashi, Yuko
Kawashima, Takahiko
Miyata, Jun
Yoshihara, Yujiro
Takahashi, Hidehiko
Aoki, Ryuta
Nakamura, Motoaki
Ota, Haruhisa
Itahashi, Takashi
Morita, Susumu
Kawakami, Shintaro
Abe, Osamu
Okada, Naohiro
Kunimatsu, Akira
Yamashita, Ayumu
Yamashita, Okito
Imamizu, Hiroshi
Morimoto, Jun
Okamoto, Yasumasa
Murai, Toshiya
Hashimoto, Ryu-Ichiro
Kasai, Kiyoto
Kawato, Mitsuo
Koike, Shinsuke
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: Increasing evidence suggests that psychiatric disorders are linked to alterations in the mesocorticolimbic dopamine-related circuits. However, the common and disease-specific alterations remain to be examined in schizophrenia (SCZ), major depressive disorder (MDD), and autism spectrum disorder (ASD). Thus, this study aimed to examine common and disease-specific features related to mesocorticolimbic circuits.
Methods: This study included 555 participants from four institutes with five scanners: 140 individuals with SCZ (45.0% female), 127 individuals with MDD (44.9%), 119 individuals with ASD (15.1%), and 169 healthy controls (HC) (34.9%). All participants underwent resting-state functional magnetic resonance imaging. A parametric empirical Bayes approach was adopted to compare estimated effective connectivity among groups. Intrinsic effective connectivity focusing on the mesocorticolimbic dopamine-related circuits including the ventral tegmental area (VTA), shell and core parts of the nucleus accumbens (NAc), and medial prefrontal cortex (mPFC) were examined using a dynamic causal modeling analysis across these psychiatric disorders.
Results: The excitatory shell-to-core connectivity was greater in all patients than in the HC group. The inhibitory shell-to-VTA and shell-to-mPFC connectivities were greater in the ASD group than in the HC, MDD, and SCZ groups. Furthermore, the VTA-to-core and VTA-to-shell connectivities were excitatory in the ASD group, while those connections were inhibitory in the HC, MDD, and SCZ groups.
Conclusion: Impaired signaling in the mesocorticolimbic dopamine-related circuits could be an underlying neuropathogenesis of various psychiatric disorders. These findings will improve the understanding of unique neural alternations of each disorder and will facilitate identification of effective therapeutic targets. |
| 書誌情報 |
en : Psychiatry and Clinical Neurosciences
巻 77,
号 6,
p. 345-354,
発行日 2023-03-11
|
| 出版者 |
|
|
出版者 |
Wiley |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1440-1819 |
| 出版者版DOI |
|
|
関連タイプ |
isReplacedBy |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/pcn.13542 |
| 出版者版URI |
|
|
関連タイプ |
isReplacedBy |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://onlinelibrary.wiley.com/doi/10.1111/pcn.13542 |
| 権利 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A92023 The Authors. This is an open access article under the terms of theCreative Commons AttributionLicense, which permits use, distribution and reproduction in any medium,provided the original work is properly cited. |
| 著者版フラグ |
|
|
出版タイプ |
NA |
