| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-04 |
| タイトル |
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|
タイトル |
Ultra-high-field pharmacological functional MRI of dopamine D1 receptor-related interventions in anesthetized rats |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
BOLD |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
brain imaging |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
dopamine D1 receptor |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pharmacological functional MRI |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ultra-high-field MRI |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Kimura, Yuka
Nakazawa, Shunsuke
Nishigori, Kantaro
Mori, Yuki
Ichihara, Junji
Yoshioka, Yoshichika
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The dopamine D1 receptor (D1R) is associated with schizophrenia, Parkinson's disease, and attention deficit hyperactivity disorder. Although the receptor is considered a therapeutic target for these diseases, its neurophysiological function has not been fully elucidated. Pharmacological functional MRI (phfMRI) has been used to evaluate regional brain hemodynamic changes induced by neurovascular coupling resulting from pharmacological interventions, thus phfMRI studies can be used to help understand the neurophysiological function of specific receptors. Herein, the blood oxygenation level-dependent (BOLD) signal changes associated with D1R action in anesthetized rats was investigated by using a preclinical ultra-high-field 11.7-T MRI scanner. PhfMRI was performed before and after administration of the D1-like receptor agonist (SKF82958), antagonist (SCH39166), or physiological saline subcutaneously. Compared to saline, the D1-agonist induced a BOLD signal increase in the striatum, thalamus, prefrontal cortex, and cerebellum. At the same time, the D1-antagonist reduced the BOLD signal in the striatum, thalamus, and cerebellum by evaluating temporal profiles. PhfMRI detected D1R-related BOLD signal changes in the brain regions associated with high expression of D1R. We also measured the early expression of c-fos at the mRNA level to evaluate the effects of SKF82958 and isoflurane anesthesia on neuronal activity. Regardless of the presence of isoflurane anesthesia, c-fos expression level was increased in the region where positive BOLD responses were observed with administration of SKF82958. These findings demonstrated that phfMRI could be used to identify the effects of direct D1 blockade on physiological brain functions and also for neurophysiological assessment of dopamine receptor functions in living animals. |
| 書誌情報 |
en : Pharmacology Research & Perspectives
巻 11,
号 2,
発行日 2023-02-19
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| 出版者 |
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出版者 |
Wiley |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2052-1707 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/prp2.1055 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.1055 |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. $00A9 2023 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. |
| 著者版フラグ |
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|
出版タイプ |
NA |
