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Mechanical regulation of synapse formation and plasticity
http://hdl.handle.net/10061/0002000186
http://hdl.handle.net/10061/00020001866a34f7d5-548d-4271-8554-52b99bdb0f50
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-03-28 | |||||||
| タイトル | ||||||||
| タイトル | Mechanical regulation of synapse formation and plasticity | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Synaptic plasticity | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | BAR-domain protein | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Shootin1 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Cadherin | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | L1 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Laminin | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| 著者 |
嶺岸, 卓德
× 嶺岸, 卓德× Kastian, Ria Fajarwati
× 稲垣, 直之 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Dendritic spines are small protrusions arising from dendrites and constitute the major compartment of excitatory post-synapses. They change in number, shape, and size throughout life; these changes are thought to be associated with formation and reorganization of neuronal networks underlying learning and memory. As spines in the brain are surrounded by the microenvironment including neighboring cells and the extracellular matrix, their protrusion requires generation of force to push against these structures. In turn, neighboring cells receive force from protruding spines. Recent studies have identified BAR-domain proteins as being involved in membrane deformation to initiate spine formation. In addition, forces for dendritic filopodium extension and activity-induced spine expansion are generated through cooperation between actin polymerization and clutch coupling. On the other hand, force from expanding spines affects neurotransmitter release from presynaptic terminals. Here, we review recent advances in our understanding of the physical aspects of synapse formation and plasticity, mainly focusing on spine dynamics. | |||||||
| 書誌情報 |
en : Seminars in Cell & Developmental Biology 巻 140, p. 82-89, 発行日 2022-06-01 |
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| 出版者 | ||||||||
| 出版者 | Elsevier | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1096-3634 | |||||||
| 出版者版DOI | ||||||||
| 関連タイプ | isReplacedBy | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1016/j.semcdb.2022.05.017 | |||||||
| 出版者版URI | ||||||||
| 関連タイプ | isReplacedBy | |||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1084952122001744?via%3Dihub | |||||||
| 権利 | ||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| 権利情報 | $00A9 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | NA | |||||||
