| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-03-19 |
| タイトル |
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タイトル |
Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
alveolar macrophage |
| キーワード |
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主題Scheme |
Other |
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主題 |
cross-presentation |
| キーワード |
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主題Scheme |
Other |
|
主題 |
resident memory CD8+ T cell |
| キーワード |
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主題Scheme |
Other |
|
主題 |
influenza A virus |
| キーワード |
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主題Scheme |
Other |
|
主題 |
IL-18 |
| キーワード |
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主題Scheme |
Other |
|
主題 |
dendritic cell |
| キーワード |
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主題Scheme |
Other |
|
主題 |
antigen presentation |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
川﨑, 拓実
Ikegawa, Moe
Yunoki, Kosuke
大谷, ひふみ
織, 大祐
Ishii, Ken J.
Kuroda, Etsushi
Takamura, Shiki
Kitabatake, Masahiro
Ito, Toshihiro
磯谷, 綾子
河合, 太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Lung CD8+ memory T cells play central roles in protective immunity to respiratory viruses, such as influenza A virus (IAV). Here, we find that alveolar macrophages (AMs) function as antigen-presenting cells that support the expansion of lung CD8+ memory T cells. Intranasal antigen administration to mice subcutaneously immunized with antigen results in a rapid expansion of antigen-specific CD8+ T cells in the lung, which is dependent on antigen cross-presentation by AMs. AMs highly express interleukin-18 (IL-18), which mediates subsequent formation of CD103+CD8+ resident memory T (TRM) cells in the lung. In a mouse model of IAV infection, AMs are required for expansion of virus-specific CD8+ T cells and CD103+CD8+ TRM cells and inhibiting virus replication in the lungs during secondary infection. These results suggest that AMs instruct a rapid expansion of antigen-specific CD8+ T cells in lung, which protect the host from respiratory virus infection. |
| 書誌情報 |
en : Cell Reports
巻 41,
号 11,
発行日 2022-12-13
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| artnum |
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値 |
111828 |
| 出版者 |
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出版者 |
Cell Press |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2211-1247 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.celrep.2022.111828 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.sciencedirect.com/science/article/pii/S221112472201720X?via%3Dihub |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A9 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
NA |
